Herbal Viagra actually contains the real thing

IF IT looks too good to be true, it probably is. Several "herbal remedies" for erectile dysfunction sold online actually contain the active ingredient from Viagra.

Michael Lamb at Arcadia University in Glenside, Pennsylvania, and colleagues purchased 10 popular "natural" uplifting remedies on the internet and tested them for the presence of sildenafil, the active ingredient in Viagra. They found the compound, or a similar synthetic drug, in seven of the 10 products – cause for concern because it can be dangerous for people with some medical conditions.

Lamb's work was presented last week at the American Academy of Forensic Sciences meeting in Washington DC.

This article appeared in print under the headline "Herbal Viagra gets a synthetic boost"

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Smartphone projector breathes life into storybooks

Hal Hodson, technology reporter

Remember your favourite storybook from childhood? Now imagine that the characters that graced its pages didn't only appear in print, but acted out scenes right in front of you, à la magic Harry Potter paintings.

HideOut, a smartphone projector system developed by Karl Willis at Disney Research in Pittsburgh, Pennsylvania, does exactly that by using invisible-ink markers to guide the projected characters of a storybook through an entire other layer of activities.

The projector also lets the user move a digital, animated character over surfaces in the real world. By passing the camera over another of the hidden patterns - which are visible only in infrared - the character can even seem to interact with physical obstacles, as in the video above.

In a paper describing the system, presented this month at the Tangible, Embedded and Embodied Interaction conference in Barcelona, Spain, Willis laid out how projection will move past games and playing to become an important computer-human interaction technology, freeing digital content from the screens.

Willis writes that future smartphones with embedded projectors will be used to browse digital files projected on any wall or table, to augment theme parks with digital characters, or to make digital board games that jump out of the table. "Enabling projected content to be mapped onto everyday surfaces from mobile devices is an important step towards seamless interaction between the digital and physical worlds."

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First mind-reading implant gives rats telepathic power

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The world's first brain-to-brain connection has given rats the power to communicate by thought alone.

"Many people thought it could never happen," says Miguel Nicolelis at Duke University in Durham, North Carolina. Although monkeys have been able to control robots with their mind using brain-to-machine interfaces, work by Nicolelis's team has, for the first time, demonstrated a direct interface between two brains – with the rats able to share both motor and sensory information.

The feat was achieved by first training rats to press one of two levers when an LED above that lever was lit. A correct action opened a hatch containing a drink of water. The rats were then split into two groups, designated as "encoders" and "decoders".

An array of microelectrodes – each about one hundredth the width of a human hair – was then implanted in the encoder rats' primary motor cortex, an area of the brain that processes movement. The team used the implant to record the neuronal activity that occurs just before the rat made a decision in the lever task. They found that pressing the left lever produced a different pattern of activity from pressing the right lever, regardless of which was the correct action.

Next, the team recreated these patterns in decoder rats, using an implant in the same brain area that stimulates neurons rather than recording from them. The decoders received a few training sessions to prime them to pick the correct lever in response to the different patterns of stimulation.

Implants linked

The researchers then wired up the implants of an encoder and a decoder rat. The pair were given the same lever-press task again, but this time only the encoder rats saw the LEDs come on. Brain signals from the encoder rat were recorded just before they pressed the lever and transmitted to the decoder rat. The team found that the decoders, despite having no visual cue, pressed the correct lever between 60 and 72 per cent of the time.

The rats' ability to cooperate was reinforced by rewarding both rats if the communication resulted in a correct outcome. Such reinforcement led to the transmission of clearer signals, improving the rats' success rate compared with cases where decoders were given a pre-recorded signal. This was a big surprise, says Nicolelis. "The encoder's brain activity became more precise. This could have happened because the animal enhanced its attention during the performance of the next trial after a decoder error."

If the decoders had not been primed to relate specific activity with the left or right lever prior to the being linked with an encoder, the only consequence would be that it would have taken a bit more time for them to learn the task while interacting with the encoder, says Nicolelis. "We simply primed the decoder so that it would get the gist of the task it had to perform." In unpublished monkey experiments doing a similar task, the team did not need to prime the animals at all.

In a second experiment, rats were trained to explore a hole with their whiskers and indicate if it was narrow or wide by turning to the left or right. Pairs of rats were then connected as before, but this time the implants were placed in their primary somatosensory cortex, an area that processes touch. Decoder rats were able to indicate over 60 per cent of the time the width of a gap that only the encoder rats were exploring.

Finally, encoder rats were held still while their whiskers were stroked with metal bars. The researchers observed patterns of activity in the somatosensory cortex of the decoder rats that matched that of the encoder rats, even though the whiskers of the decoder rats had not been touched.

Pairs of rats were even able to cooperate across continents using cyberspace. Brain signals from an encoder rat at the Edmond and Lily Safra International Institute of Neuroscience of Natal in Brazil were sent to a decoder in Nicolelis's lab in North Carolina via the internet. Though there was a slight transmission delay, the decoder rat still performed with an accuracy similar to those of rats in closer proximity with encoders.

Wake-up call

Christopher James at the University of Warwick, UK, who works on brain-to-machine interfaces for prostheses, says the work is a "wake-up call" for people who haven't caught up with recent advances in brain research.

We have the technology to create implants for long-term use, he says. What is missing, though, is a full understanding of the brain processes involved. In this case, Nicolelis's team is "blasting a relatively large area of the brain with a signal they're not sure is 100 per cent correct," he says.

That's because the exact information being communicated between the rats' brains is not clear. The brain activity of the encoders cannot be transferred precisely to the decoders because that would require matching the patterns neuron for neuron, which is not currently possible. Instead, the two patterns are closely related in terms of their frequency and spatial representation.

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US nuclear dump is leaking toxic waste

Waste from the production of US nukes is on the loose. Toxic cargo is escaping from six of the 177 ageing tanks at the Hanford site in Washington state where the nation stores two-thirds of its high-level nuclear waste, most of it from the production of nuclear bombs.

The site houses 200 million litres of radioactive and hazardous waste, and 67 tanks have leaked waste before. The new leaks undermine recent reassurances that the dump is now secure.

The biggest worry is that highly radioactive sludges containing heat-generating isotopes are corroding the bottoms of the tanks, following work to drain off most of the liquid waste which allowed the isotopes to collect there, says Bob Alvarez of the Institute of Policy Studies in Washington DC.

"There is no immediate public health risk," said Lindsey Geisler, a spokesperson for the Department of Energy. However, much of the waste has already contaminated groundwater, says Tom Carpenter of Hanford Challenge, an environmental watchdog in Seattle, Washington.

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China takes steps to clean up 'cancer villages'

The Chinese government has acknowledged the existence of "cancer villages": areas where rates of cancer are unusually high, probably because of industrial and agricultural contamination of drinking and irrigation water.

The reference to the cancer clusters was in China's first ever five-year plan for environmental management of chemicals, released on 20 February. The Chinese media, translating parts of the report, said it links water pollution to "serious cases of health and social problems like the emergence of cancer villages in individual regions".

The term has caught on over the past few years as the media in China and elsewhere reported on apparent cancer hotspots. It gained prominence in 2009 when a journalist plotted 40 of them on a Google Map. Some reports have suggested there might be more than 450 such clusters.

According to recent data, deaths from cancer in China increased by 80 per cent between 1970 and 2004. The disease now accounts for 25 per cent of deaths in cities and 21 per cent in rural areas. However, people in China have an 18.9 per cent risk of getting cancer before the age of 75, compared with 29.9 per cent for people in the US and 26.3 per cent in the UK.

One "typical cancer village", as it was called by researchers from Dezhou University in Shandong province who studied it in 2008, had between 80 and 100 deaths from cancer over five years in a population of only 1200.

But proving a link between pollution and cancer requires more detailed evidence, says Tim Driscoll, an epidemiologist at the University of Sydney and science adviser to Cancer Council Australia. However, Driscoll also says it doesn't really matter – if there is dangerous pollution anywhere, it should be cleaned up.

And that is the plan. China's Ministry for Environmental Protection has drawn up a list of 58 chemicals that will be tracked with a registry, including known and suspected carcinogens and endocrine disrupters. Before the end of the 2015, they will subdivide the list into chemicals to be eliminated and those to be reduced.

Big shift

Creating a plan to eliminate some chemicals is a big shift, says Yixiu Wu, a Greenpeace East Asia campaigner based in Beijing, who says even committing to controlling these chemicals would have been a step forward.

The ministry's acknowledgement of the problem is "really important and it is another reflection of the government's shift towards more transparency in pollution information," says Sabrina Orlins from the Institute of Public and Environmental Affairs, a non-profit body in Beijing.

"Increased environmental information leads to increased public awareness where people can have the chance to exert pressure on big water polluters to adopt clean-up measures and be more accountable," she says.

That accountability is where the five-year plan is lacking, says Wu. "It is still a question whether the government is willing to release all the information about the factory locations and their environmental risk," she says. "It is very important for people who are living nearby."

Wu says the motivation to develop the plan comes from an increasing awareness of the human cost of pollution as well as the country signing up to several international conventions designed to curb pollution.

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Armband adds a twitch to gesture control

And you thought depth-sensing cameras were cool: well, now there's a gesture control device that looks like a sweatband. It lets you control everything from computers to flying drones just by moving the muscles in your forearm.

The Myo, built by Canadian startup firm Thalmic Labs, based in Kitchener, Ontario, aims to bring gestural interfaces right into the mainstream. Electrodes embedded in the band read electrical activity in a user's muscles as they contract or relax to make gestures with their hand and arm, and transmit it wirelessly to software that interprets the movements into commands.

"We really have this belief that technology can be used to enhance our abilities," says Stephen Lake, co-founder of Thalmic Labs. "This is a way of using natural actions that we've evolved to intuitively control the digital world."

Lake and his team built Myo using electrodes that work without making direct contact with the skin, unlike medical electrodes. The first generation can recognise around 20 gestures, some as subtle as the tap of a finger – and it is programmed to ignore random noise generated by other body movements.

Myo's creators envision it as an easy way to interact with everything from web browsers to video games to small drones. The first generation of the product, is expected to cost $149 and ship later this year. It will come with software that will allow any Windows or Apple Mac machine to recognise the gestures we use on touchscreens – like a vertical swipe to scroll down a page, or a pinch to zoom.

"It's not very often that a new, affordable and convenient interface technology comes along, so I think a lot of programmers are going to want to try it," says Trevor Blackwell, founder of robotics company Umbrella Research and a partner in Y Combinator. This startup incubator programme is based in Mountain View, California and has provided Thalmic Labs with funding in exchange for a 7 per cent stake in the company. "I think so far we've only thought of around 1 per cent of its potential applications."

Thalmic Labs is not the first firm to try making a device that recognises gestures by sensing muscle activity. In 2008, Microsoft created a prototype called MUCI that worked in a similar fashion to Myo, but needed medical electrodes, which are not feasible outside of a laboratory setting.

There are also devices that use cameras to precisely track users' hand motions, but they are either in early stages of development, or not portable. "Maybe this couldn't have been foreseen by early researchers working with cameras, but people don't like having cameras watching them all the time," Blackwell says. "Thalmic solves that problem nicely." Though the first generation of Myo is only just launching, the team is already imagining ways to integrate their rigs with augmented reality devices like the head-mounted display, Google Glass.

"If they combined with Google's Project Glass, I think it would be huge," says computer scientist Shahzad Malik, who co-founded the software company CognoVision of Toronto. "Something like Thalmic's technology is super-useful since you can do interactions in a subtle way, which is important when you're in a public venue."

"We're interested in seeing just how closely we can integrate technology into our daily lives and give people superpowers, if you like," says Lake.

Wear tech... look great?

Making wearable technology fashionable is tough – think belt-mounted cellphones, beepers, and bluetooth ear pieces. But iPod earbuds and headphones seem to work.

How do you get the mix right? Google is working hard to make Project Glass rigs look hip, even convincing clothing designer Diane von Fürstenberg and her models to wear prototypes of the head-mounted displays at Fashion Week in New York last year.

Myo bands (see main story) could be an easier sell , says computer scientist Shahzad Malik. "I could see these bands becoming smaller and smaller, or are made in different colours. Or there could be clothing with it built in," he says.

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New blood test finds elusive fetal gene problem

A NEW non-invasive blood test for pregnant women could make it easier to catch abnormalities before their child is born.

Human cells should have two copies of each chromosome but sometimes the division is uneven. Existing tests count the fragments of placental DNA in the mother's blood. If the fragments from one chromosome are unusually abundant, it might be because the fetus has an extra copy of that chromosome. But triploidy, where there are three copies of every chromosome, is missed, since the proportion of fragments from each chromosome is the same.

California-based company Natera uses an algorithm to calculate the most likely genotype for the fetus. To do this it looks at single letter variations called SNPs in the parents and compares this to a database of the most common SNPs patterns in the population. This genotype is then compared with placental DNA.

This approach can catch triploidy since the whole fetal genotype is the reference rather than a single chromosome. The method was presented last week at the Society for Maternal-Fetal Medicine in San Francisco.

This article appeared in print under the headline "No hiding place for fetal gene errors"

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Amazon to open market in second-hand MP3s and e-books

A new market for second-hand digital downloads could let us hold virtual yard sales of our ever-growing piles of intangible possessions

WHY buy second-hand? For physical goods, the appeal is in the price – you don't mind the creases in a book or rust spots on a car if it's a bargain. Although digital objects never lose their good-as-new lustre, their very nature means there is still uncertainty about whether we actually own them in the first place, making it tricky to set up a second-hand market. Now an Amazon patent for a system to support reselling digital purchases could change that.

Amazon's move comes after last year's European Union ruling that software vendors cannot stop customers from reselling their products. But without technical support, the ruling has had no impact. In Amazon's system, customers will keep their digital purchases – such as e-books or music – in a personal data store in the cloud that only they can access, allowing them to stream or download the content.

This part is like any cloud-based digital locker except that the customer can resell previous purchases by passing the access rights to another person. Once the transaction is complete, the seller will lose access to the content. Any system for reselling an e-book, for example, would have to ensure that it is not duplicated in the transaction. That means deleting any copies the seller may have lying around on hard drives, e-book readers, and other cloud services, since that would violate copyright.

Amazon may be the biggest company to consider a second-hand market, but it is not the first. ReDigi, based in Boston, has been running a resale market for digital goods since 2011. After downloading an app, users can buy a song on ReDigi for as little as 49 cents that would costs 99 cents new on iTunes.

When users want to sell an item, they upload it to ReDigi's servers via a mechanism that ensures no copy is made during the transfer. Software checks that the seller does not retain a copy. Once transferred, the item can be bought and downloaded by another customer. ReDigi is set to launch in Europe in a few months.

Digital items on ReDigi are cheaper because they are one-offs. If your hard drive crashes and you lose your iTunes collection you can download it again. But you can only download an item from ReDigi once – there is no other copy. That is the trade-off that makes a second-hand digital market work: the risk justifies the price. The idea has ruffled a few feathers – last year EMI sued ReDigi for infringement of copyright. A judge denied the claim, but the case continues.

Used digital goods can also come with added charm. ReDigi tracks the history of the items traded so when you buy something, you can see who has owned it and when. ReDigi's second-hand marketplace has grown into a social network. According to ReDigi founder John Ossenmacher, customers like seeing who has previously listened to a song. "It's got soul like an old guitar," he says. "We've introduced this whole feeling of connectedness."

It could be good for business too if the original vendors, such as iTunes, were to support resale and take a cut of the resell price. Nevertheless, Amazon's move bucks the industry trend. Microsoft's new Xbox, for example, is expected not to work with second-hand games.

But the market could change rapidly now that Amazon's weight is behind this, says Ossenmacher. "The industry is waking up."

This article appeared in print under the headline "Old MP3, one careful owner"

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First MRI movies capture fetal brain connecting up

Sandrine Ceurstemont, editor, New Scientist TV

It's the sequel to fertilisation:
the brains of unborn babies have now been imaged in action, showing how connections form.

This fMRI movie, produced by Moriah Thomason from Wayne State University in Detroit, Michigan, shows a fly-through of several fetuses in their third trimester. By comparing the scans at slightly different stages of development, Thomason was able to pinpoint when different parts of the brain wire up. "The connection strength increases with fetal age," writes Thomason.

By identifying how brain connectivity normally develops, the scans could help diagnose and treat conditions like schizophrenia and autism before birth. For more on this research, read our full-length news story, "First snaps made of fetal brains wiring themselves up".

If you enjoyed this post, watch a baby's birth captured in an MRI machine for the first time
or see the first video MRI of unborn twins.

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Sharing and streaming at heart of new PlayStation 4

Douglas Heaven, reporter

Sony's Andrew House introduces the PlayStation 4 at a news conference yesterday (Image: Emmanuel Dunand/AFP/Getty Images)

It's typically only spoilt children and brilliant eccentrics that get away with not turning up to their own party. Sony's long-awaited announcement last night of the PlayStation 4 games console - its successor to the seven-year-old and 70-million-selling PS3 - put an end to speculation, but was most notable for the no-show of the console itself. Was this meant to prolong the hype until the "Holiday 2013" launch, as Sony claims, or because the company hasn't yet solved cooling problems, as cynics have suggested?

What we do have is an official spec sheet which reads more like one for a supercharged PC. The PS4 specs certainly carry enough punch to support spectacular graphics by today's standards, and a large part of last night's show was devoted to showing this off. But will it still feel fresh in seven years when PC architecture has moved on?

The key new technology in this console generation is likely to be the live streaming of games. After acquiring Gakai - one of the pioneers of game-streaming technology - Sony is leading the way and making live streaming a big part of the player experience.

This has let Sony build game spectating into the hardware: the console will continuously encode a video stream of your game footage while you play. A "share" button on the new controller will then let you immediately start streaming video of your in-game play to friends.

Friends may even be able to jump in remotely and lend a hand if you get stuck, either by taking temporary control for that infuriating boss fight or by acting as a game director who drops helpful items into your game.

Streaming tech will also let you jump in and play demos of games in the online PlayStation Store, something that's only possible now by waiting out a lengthy download. Personalisation is also getting a big push: The PlayStation Store will learn what type of games you like, and possibly even take the liberty of pre-empting a purchase by downloading games it thinks you might want to buy to your console's hard disc.

Backwards compatibility with PS3 games isn't clear. Older games - including titles from the original PlayStation and PS2 - will be available via streaming, but Sony hasn't yet said whether this will require repurchasing an entire games collection. However, physical copies of second-hand games may well be supported, according to Eurogamer, which apparently puts Sony at odds with Microsoft.

Finally, Sony says it wants all PS4 games to be playable on mobile devices - the PlayStation Vita and possibly certain phones and tablets - again by streaming directly from the PS4 via Wi-Fi. This could be handy if you want to play while someone else hogs the widescreen TV.

The take-home message is that Sony's new console wants to be the centre of a new kind of gaming experience - one that's more social, more flexible, more mobile. Pity it's still stage-shy.

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Today on New Scientist: 19 February 2013

Doctors would tax sugary drinks to combat obesity

Hiking the price of fizzy drinks would cut consumption and so help fight obesity, urges the British Academy of Medical Royal Colleges

Space station's dark matter hunter coy about findings

Researchers on the Alpha Magnetic Spectrometer, which sits above the International Space Station, have collected their first results - but won't reveal them for two weeks

Huge telescopes could spy alien oxygen

Hunting for oxygen in the atmospheres of distant exoplanets is a tough job, but a new wave of giant telescopes should be up to the task

Evolution's detectives: Closing in on missing links

Technology is taking the guesswork out of finding evolution's turning points, from the first fish with legs to our own recent forebears, says Jeff Hecht

Moody Mercury shows its hidden colours

False-colour pictures let us see the chemical and physical landscape of the normally beige planet closest to the sun

LHC shuts down to prepare for peak energy in 2015

Over the next two years, engineers will be giving the Large Hadron Collider the makeover it needs to reach its maximum design energy

Insert real news events into your mobile game

From meteor airbursts to footballing fracas, mobile games could soon be brimming with news events that lend them more currency

3D-printing pen turns doodles into sculptures

The 3Doodle, which launched on Kickstarter today, lets users draw 3D structures in the air which solidify almost instantly

We need to rethink how we name exoplanets

Fed up with dull names for exoplanets, Alan Stern and his company Uwingu have asked the public for help. Will it be so long 2M 0746+20b, hello Obama?

A shocking cure: Plug in for the ultimate recharge

An electrical cure for ageing attracted the ire of the medical establishment. But could the jazz-age inventor have stumbled upon a genuine therapy?

Biofuel rush is wiping out unique American grasslands

Planting more crops to meet the biofuel demand is destroying grasslands and pastures in the central US, threatening wildlife

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Insert real news events into your mobile game

Paul Marks, chief technology correspondent

(Image: MultiPlay.io)

Seen it in the news? Now play it: a mobile-game programming system allows 3D depictions of news events to be introduced into the action. It's been developed by MultiPlay.io, a British start-up that says the technology could make gameplay more current and provide new ways for designers and coders to make cash - perhaps selling "news injection" rights to news agencies, TV stations or newspapers.

The firm's HTML5 games creator, also called MultiPlay.io, lets users import 3D animations during gameplay, allowing, for instance, last week's meteor explosion over Russia to be pasted in above the game action, says one of the company's founders, Ashraf Samy Hegab. Similarly, he says, if a millionaire footballer hits the news in, say, a fight with a nightclub bouncer, lookalike avatars could engage in just such a fracas as you motor by in a driving game.

The system creates games for Apple iOS, Google Android and Windows Phone devices. Changes to games need to be made in a browser on a PC or Mac, but can be made in real time without you having to download an app update.

"We're using a clever way of splitting the game logic that lets you change the game on the fly, as easy as a drag-and-drop task in a browser," says Hegab. "You don't need to know anything about servers or 3D programming using our engine." The idea also lets you extend the game's virtual playing area by expanding the game map, or add 3D vehicles you've designed yourself, such as glitzy spacecraft or cars. You could even add a model of yourself.

But news injection is MultiPlay.io's main aim - and its founders are hoping to interest news agencies when Mobile World Congress kicks off in Barcelona, Spain, later this month. They are not alone: adding news to make games more relevant is becoming popular, with some websites beginning to offer games with news-related activities built in, such as the fascinating Game The News, which "creates its own twists on news events in a playable form".

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The fish with a rainbow eye

Michael Marshall, environment reporter

(Image: Randall Benton/The Sacramento Bee)

These eyes are positively spectral. They belong to a Caribbean trumpetfish, and their many colours are created by the refraction of light.

Rays of light bend as they pass in and out of the fish's eyes, and different colours of light bend different amounts. As a result, what was previously white light splinters into bands of different colours, like a rainbow. From bottom to top in the photo, the colours in the eye follow part of the usual rainbow sequence, from orange to blue.

Like all trumpetfish, Aulostomus maculatus has a long thin body rather like that of an eel. It often swims vertically, disguising itself among vertical corals. But it also camouflages itself by swimming along the lateral lines of larger fish.

The photograph, by Randall Benton, has just won third prize in the Nature category of the World Press Photo of the Year awards 2012.

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False memories prime immune system for future attacks

IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.

When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.

Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.

The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.

The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."

So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.

To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).

The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.

"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"

This article appeared in print under the headline "False memories prime our defences"

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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False memories prime immune system for future attacks

IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.

When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.

Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.

The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.

The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."

So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.

To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).

The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.

"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"

This article appeared in print under the headline "False memories prime our defences"

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Brecht's Galileo is a play for our times

Tiffany O'Callaghan, Opinion editor

Ian McDiarmid as Galileo (left) and James Tucker as the Bursar (Image: Ellie Kurtz)

It has been more than 400 years since Galileo Galilei pointed his telescope toward the night sky and observed the movement of the moons around Jupiter, providing proof that all things do not revolve around the Earth - and drawing the ire of the Catholic church.

And it has been nearly 80 years since playwright Bertolt Brecht wrote the first version of A Life of Galileo while living in Denmark after fleeing Germany when Hitler took power.

Yet the latest retelling of this famous tale by the Royal Shakespeare Company underscores the emphatically contemporary nature of the struggle between static world views and dynamic knowledge.

This is reinforced by using the familiar, modern clothing of tweedy dishevelment among Galileo and his colleagues and pupils, and sets featuring the lab-staple whiteboard and a large blue backdrop that resembles a wall of solar panels.

But of course this is not simply an old story with modern accoutrements and gimmicky staging. Portrayed by Ian McDiarmid, Galileo’s compulsive curiosity, his sheer joy when his pupil grasps a new concept for the first time, and his bewildered frustration when adversaries refuse to observe the evidence literally in front of them feel both timely and timeless. “All I ask is for them to believe their eyes!” exclaims poor Galileo.

In a moment when 46 per cent of US citizens believe the Earth is less than 10,000 years old and four US states are weighing up bills that would challenge the teaching of evolution, the tension remains strong between theologies that carve out a creation story for humans and the evidence that we are the serendipitous result of millions of years of evolution.

There are strong reminders of these tensions in the play, for example, when a cleric bullies Galileo to keep his heliocentric ideas to himself, crystallising the church’s terror at the implications of his ideas: “Is no one watching us?" asks the cleric. "Has no one imagined a part for us to play other than this one?”

Galileo is cowed into compromise. His new ideas may be used to help seafarers better navigate by the stars, but not to upend the understanding of the order of things. They may answer practical questions, but not existential ones. “We may research, but we may not draw conclusions.”

He accepts the new conditions in word only. His experiments continue, and when given the slimmest opening his feverish curiosity breaks out into the light of day. When he learns that his friend and science enthusiast Cardinal Barberini may ascend to the papacy, he lauds the arrival of an era of reason. Too soon, of course.

In the second act, we meet the new pope in his undergarments. As he debates the use of torture and threats to force Galileo to renounce the Copernican ideas laid out in his Dialogue Concerning the Two Chief World Systems, Barberini dons layer upon layer of vestments. Crimson robes, a glittering great cape, and finally the mitre: when he is cloaked in the power of his office, Barberini assents to the threat of torture.

The scene parallels the opening scene of the play, in which Galileo, also in only his undergarments, is bathing and getting ready for the day. The contrast is evident: in the flesh, they are both ageing men. But their power to spread ideas is proportional to the grandeur of their garments. When Galileo is threatened and ultimately abjures his earlier assertions, he returns beaten and bare-legged in a crumpled white gown.

The legacy of Galileo’s recantation is left open. Brecht rewrote aspects of the play following the bombings of Hiroshima and Nagasaki in 1945, when he was living in the US. “Overnight the biography of the founder of the new system of physics read differently,” he wrote in an introduction to the new version. “The infernal effect of the great bomb placed the conflict between Galileo and the authorities of his day in a new sharper light.”

Brecht never saw the stage production of his later version in New York, as he left the country after being questioned by the House Committee on Un-American Activities.

By the end of the play, Galileo is wary of science shaped by interests more nefarious than the quest for truth. He sees a danger in scientists being reduced to little more than “inventing pygmies” for sale to the highest bidder, their ideas open to be used for cruel ends. Galileo’s public recantation and private pursuit of truth and Brecht’s ambivalence about the responsibility of scientists to shape the use of their research for the benefit of humankind are not necessarily two sides of the same coin, it seems.

But it isn’t clear that in publicly defying the church Galileo would have reshaped the way that scientific knowledge is applied. And in real life, as in the play, in sneaking his final, influential publication Discourse and Mathematical Demonstrations About Two New Sciences out under the noses of the church which held him under house arrest for the final years of his life, Galileo seems vindicated in his decision to live to think another day.

As New Yorker critic Adam Gopnik recently put it, “the best reason we have to believe in the moons of Jupiter is that no one has to be prepared to die for them in order for them to be real”.

It may be an excruciatingly slow process, but the truth has a way of emerging into the light eventually. It was just two decades ago - and 350 years after Galileo’s death - that the Catholic church finally admitted that it had been wrong to condemn him.

A Life of Galileo is on at the Swan Theatre, Stratford-upon-Avon, UK, until 30 March.

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Runaway stars to fill in the blanks in Milky Way map

GUIDES to the galaxy might call it Zona Galactica Incognita – the half of our home galaxy we know little about. Indeed, the Milky Way is one of the least charted spiral galaxies in the nearby universe. Now it seems that stars kicked out of their birth clusters can help fill in the void and create the first proper map of the entire galaxy.

Young star clusters and clouds of hydrogen that formed in our galaxy help trace the shapes of the Milky Way's arms, so astronomers are reasonably certain that it has a spiral structure (see right). Observations of stellar motion show that there is a supermassive black hole at its core.

But figuring out how fast the arms rotate or even counting how many there are is tricky, in part because we are embedded in one of its arms and unable to get an outsider's view. In addition, everything behind the galactic centre is shrouded by a dense wall of stars and dust, blanking out a whole area of the Milky Way map.

"It's quite difficult to see the actual structure," says Manuel Silva of the University of Lisbon in Portugal. "I'm a little upset, really, that we don't know our own galaxy that well."

A space telescope called Gaia, scheduled for launch later this year, will map the positions and distances of about one billion stars on our side of the Milky Way, plotting the three-dimensional structure in unprecedented detail. But even Gaia won't be able to pierce the material that blocks our view of the far side.

Instead of trying to look across, Silva and his colleagues suggest looking up, where hundreds of runaway stars fly high above the disc of the galaxy. These stars are born in clusters inside the Milky Way but get ejected during gravitational jostling with other stars. Precise measurements of their velocities, ages and distances would allow astronomers to trace the stellar fugitives back to their homes, even on the far side.

"The idea is that the runaway stars act as signal flares, showing the position of the spiral arm, the same way someone lost in the middle of a dense forest could fire one to the sky to show his or her location to an outsider," says Silva.

His team traced the origins of about 40 runaway stars, observed by the Hipparcos satellite, ranging from roughly 1000 to 100,000 light years above the galactic plane (arxiv.org/abs/1302.0761v1). Although none of these stars came from the far side, the technique seems to work because the results agreed with previous studies that mapped star clusters in the visible section of the galaxy.

"The idea is a new one, and is an interesting one," says Jacques Lepine of the University of São Paulo in Brazil, who was not involved in the new study. Comparing Gaia's view of stars with the runaways will be helpful, he adds. "It is good to have different methods, to compare results. If the results are similar, we get more confident."

Jacques Vallée of the Canadian National Research Council in Victoria, British Columbia, agrees that the proof of concept is impressive. But that doesn't stop him fantasising about easier ways: "Wish I had a friend on a planet around a runaway star in the halo, sending me back a photo."

This article appeared in print under the headline "Runaway stars flesh out Milky Way map"

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US should vaccinate poultry to stop killer salmonella

It is a case of putting the bottom line before our health. This year, a million Americans will succumb to salmonella poisoning. Several hundred will die. Yet in Europe, a cheap vaccine for chickens has slashed the number of cases. Vaccination in Iowa shows US lives can be saved too – but US rules give meat producers no incentive to use a vaccine that doesn't boost their profits.

Salmonella causes more deaths than any other food-borne germ and is the second-most common cause of food-borne illness in the US, according to a new report published by the US Centers for Disease Control and Prevention in Atlanta, Georgia. Poultry, meat and eggs are the biggest source, causing a third of all cases.

But this can be prevented. After a scandal over infected eggs in the UK in the late 1980s, farmers boosted hygiene standards and killed infected flocks. Human cases stayed high until 1998 when British supermarkets started buying eggs only from vaccinated hens, says Sarah O'Brien of the University of Liverpool, UK. Human cases then plummeted with a forty-fold drop between 1993 and 2010.

In the US, a massive recall of eggs due to salmonella in 2010 similarly led to tighter hygiene rules for chicken farms. But the US Food and Drug Administration declared there was "insufficient data on efficacy" to make vaccination compulsory, despite evidence in Europe to the contrary.

Nonetheless, as monitoring programmes have revealed just how widespread the infection is, about a third of US egg producers have started to vaccinate their chickens. That and better hygiene has reduced the number of infected hen houses fivefold in Iowa, the biggest US egg producer, in the past two years, says Darrell Trampel of Iowa State University.

Meat producers have resisted, however, even though there is salmonella on 13 per cent of chicken breasts sold in US supermarkets, says Lance Price of George Washington University in Washington DC. The farmers vaccinate for several poultry diseases, but since salmonella doesn't hurt the birds or affect their growth, says Price – and human illness is not a cost the farmers have to bear – there is no motivation to prevent its spread.

Journal reference: Emerging Infectious Disease, doi.org/kgx

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Robotic tormenter depresses lab rats

Hal Hodson, technology reporter

(Image: Chris Nash/iamchrisphotography/Getty)

Lab rats have a new companion, but it's not friendly. Researchers at Waseda University in Tokyo, Japan, have developed a robotic rat called WR-3 whose job is to induce stress and depression in lab animals, creating models of psychological conditions on which new drugs can be tested.

Animal are used throughout medicine as models to test treatments for human conditions, including mental disorders like depression. Rats and mice get their sense of smell severed to induce something like depression, or are forced to swim for long periods, for instance. Other methods rely on genetic modification and environmental stress, but none is entirely satisfactory in recreating a human-like version of depression for treatment. Hiroyuki Ishii and his team aim to do better with WR-3.

(Image: Takanishi Lab/Waseda University) 

The researchers tested WR-3's ability to depress two groups of 12 rats, measured by the somewhat crude assumption that a depressed rat moves around less. Rats in group A were constantly harassed by their robot counterpart, while the other rats were attacked intermittently and automatically by WR-3, whenever they moved. Ishii's team found that the deepest depression was triggered by intermittent attacks on a mature rat that had been constantly harassed in its youth.

The team say they plan to test their new model of depression against more conventional systems, like forced swimming.

The robot has been developed just as new research by Junhee Seok of Stanford University in Palo Alto, California, and colleagues shows that the use of mouse models for human conditions has led researchers trying to find treatments for sepsis, burns and trauma astray at a cost of billions of tax dollars.

Journal reference: Advanced Robotics, DOI: 10.1080/01691864.2013.752319

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Can the internet revive US democracy?

Jim Giles, consultant

Tech-savvy campaigns get mixed results, as the Arab Spring shows (Image: William Dupuy/Picturetank)

Gavin Newsom's Citizenville shows that technology can empower people, but the book fails to explore deep-rooted problems within the democratic process

THERE'S a lot of crime in Oakland, California. But until a few years ago, citizens had little way of assessing the scale of the problem. Then Michal Migurski hurt his back. It was Christmas 2006 and Migurski, a computer programmer, was stuck at home in Oakland, looking for ways to use his time until his back healed. He knew about the area's crime problem and decided to create an online map showing where and when crimes had been committed - something local government had failed to do.

Migurski's crimespotting.org website gets enthusiastic coverage in Gavin Newsom's Citizenville, a homage to technology's ability to empower people and reform government. If committed and skilled citizens like Migurski can access official data, for example, they can create services that governments don't have time for or aren't well equipped to provide. The internet has already disrupted a swathe of industries, from journalism to telecommunications. Citizenville is packed with examples that show that it is government's turn.

For the book, Newsom - California's lieutenant governor - talked to a host of Silicon Valley luminaries, from Google founder Sergey Brin to Tim O'Reilly, tech publisher and one of the most high-profile advocates of the idea that technology can transform government. The result is a 239-page tribute to what the valley does best: suggest radical and scalable ways to do things better.

Unfortunately, Newsom's unfettered enthusiasm for the power of the internet and smartphones to transform social and governmental problems makes for a shallow read. Take his analysis of FarmVille, the incredibly successful Facebook game in which players run virtual farms. Why couldn't a similar game be used to help govern a real city, he asks? It's an intriguing idea, based in part on the argument put forward by Jane McGonigal, a game designer, that gaming can be used to solve real-world problems.

But doesn't FarmVille's appeal have much to do with its lack of real-life responsibility? Newsom only touches on this before rushing off to his next tech-inspired solution.

It's a frustrating approach because Newsom was mayor of San Francisco between 2003 and 2010, and rolled out some bold tech-based reforms during his tenure, so he is well placed to discuss the benefits and difficulties of applying technology to governance.

Some of the most interesting parts of Citizenville address ideas that did not work, like radical transparency. After becoming mayor, Newsom decided to post his diary on the web, until his chief of staff pointed out that fundraising meetings would be visible. Newsom relented, accepting that voters don't like to see politicians asking for money.

It's a great example of how technology is just part of the reform equation. To truly empower, technology will have to deal with many entrenched problems, ranging from the shameless distortions that most elected officials spout to the huge number of alienated people who don't register to vote. Any proper assessment of technology's power to change needs to do more than consider the solutions it offers. The impoverished democratic process in the US will not improve until the causes of this situation are part of the discussion.

Broader initiatives exist, of course. Political scientists who study how misinformation spreads have teamed up with technologists to create systems for reining in erroneous memes, like the claim that Barack Obama is not a US citizen. Public health experts are studying not just the internet's ability to communicate health information but also the extent to which that information changes behaviour. It is this kind of thinking, which accepts that technology is only part of the solution, that is missing from Citizenville. I was left wishing that Newsom had focused on just a few of the issues he writes about, and had taken his research beyond the confines of Silicon Valley.

This article appeared in print under the headline "There is no app for political reform"

Book information:
Citizenville: How to take the town square digital and reinvent government by Gavin Newsom and Lisa Dickey
Penguin
$25.95

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